NovelistLarryDonner(BillyCrystal)struggleswithwriter'sblockduetohisresentmenttowardshisex-wifeMargaret(KateMulgrew),whostolehisbookandgarneredmainstreamsuccessandcriticalacclaimwithit.OwenLift(DannyDeVito)isatimid,middle-agedmanwhostillliveswithhisoverbearing,abusivemother(AnneRamsey).Owenfantasizesofkillinghismotherbutcan'tsummonthecouragetobringhisdesiresintofruition.AsastudentinLarry'scommunitycollegewritingclass,OwenisgivenadvicebyLarrytoviewanAlfredHitchcockfilmtogainsomeinsightintoplotdevelopment.HeseesStrangersonaTrain,inwhichtwostrangersconspiretocommitamurderforeachother,figuringtheirlackofconnectiontothevictimwill,intheory,establishaperfectalibi.HavingoverheardLarry'spublicrantthathewishhisex-wifedead,OwenformsaplantokillMargaret,believingthatLarrywillrespondbykillinghismother. HetracksMargaretdowntoHawaiiandfollowsherontoacruiseship,apparentlypushingheroverboardwhileshetriestoretrieveanearringthatfellout.OwenreturnsfromHawaiitotellLarryofMargaret'sdeathandthatLarrynow"owes"himthemurderofhismother,lestheinformthepoliceLarrywasthekiller.AfterhavingspentthenightdrinkingaloneduringthehoursofMargaret'sdisappearance,Larrypanicsbecausehelacksasufficientalibi.That,alongwithanewsreportannouncingthepolicesuspectfoulplay,convincesLarryhe'stheprimesuspect.HedecidestostaywithOwenandhismotherinanattempttohidefromthepolice.LarrymeetsMrs.Lift,butdespiteherharshtreatmentofhimherefusestokillher.Eventually,whenMrs.LiftdrivesOwentothebreakingpoint,Larryfinallyrelentsandagreestogothroughwiththemurder. Aftertwounsuccessfulattempts,LarryfleestheLifthomewhenMrs.Liftrecognizeshimasasuspectfromanewsbroadcastabouthisex-wife'sdisappearance.HeboardsatraintoMexicoand,surprisingly,OwenandMrs.Liftcomealongsoastoavoidhavingtolieforhim.Duringthejourney,Larry'spatiencewithMrs.Liftreachesitspinnaclewhensheimpolitelygiveshimadviceonwriting.Hefollowshertothecaboosewiththeintentofthrowingherfromthetrain,butstopsshortwhenshealmostfallsoffonherown.OwenbeginshavingsecondthoughtsabouthavinghismotherkilledandcomestohelpLarryrescueher.Mrs.Liftisgratefulathersonforsavingher,butunappreciativeofLarry'shelpandkickshim,resultinginhimlosinghisbalance,landingonthetracks,andbreakinghisleg. Duringhisrecoveryinthehospital,LarrydiscoversMargaretisstillalive;shesimplyfelloverboardbyaccidentandwasrescuedbyaPolynesianfishermanwhomshehasdecidedtomarry.Muchtohisannoyance,LarrylearnsMargaretplanstoselltherightsofherordealfor$1.5milliondollars.Ontheadviceofafellowpatient,Larrychoosestofreehimselfofhisobsessionwithhisex-wifeandinsteadfocusonhisownlife,therebyfreeinghimofhiswriter'sblock. Ayearlater,LarryhasfinishedanovelbasedonhisexperienceswithOwenandMrs.LiftentitledThrowMommafromtheTrain.Owenvisitsandinformshimthathismotherhasdied(ofnaturalcauses)andthathe'sgoingtoNewYorkCityforthereleaseofhisownbook.Unfortunately,Owenrevealshisbookisalsoabouttheirexperiencestogether.Thinkinghisbookhasbeenscooped,anenragedLarryproceedstostranglehim,butstopswhenOwenshowshimthebookisachildren'spop-upbookcalled,Momma,Owen,andOwen'sFriendLarrywiththestorydrasticallyalteredtobesuitableforchildren.Monthslater,Larry,Owen,andLarry'sgirlfriendBeth(KimGreist)vacationtogetherinHawaii,reflectingonthefinalchapterofLarry'sbook.LarryandOwen'sbookshavenowbecomebest-sellers,makingthembothsuccessfulwritersaswellasclosefriends.
谭笑,张秉君,张伟,刘思奇
贾冰,尹正,倪虹洁,徐峥,丁嘉丽,王迅,杨皓宇,潘斌龙,包贝尔,于洋,刘桦,孙浩,张绍刚,夏梦,宗俊涛,赵胤胤,火风
合文俊,孙越,尹菲,曹然然,李飞,王喳喳,吕严,马旭东,林墨,鹏程,刘洋,张泰维,德柏,杜晓宇,方向,夏淳,任志达,邢三狗,天蕾大哥
威尔·法瑞尔,瑞茜·威瑟斯彭,杰拉尔丁·维斯瓦纳坦,梅瑞迪斯·海格纳,韦斯利·曼恩,吉米·塔特罗,西利亚·维斯顿,LeanneMorgan,凯拉·蒙特罗索·梅加,罗里·斯卡沃,比比·博克斯,劳伦·霍尔珀林,萨马尼·怀尔德,希德尼·威斯,JackCaron,马特·默丘里奥,劳伦·霍尔特,斯坦尼·布莱登,GinnyMacColl,米兰达·德·梅奥
崔志佳,焦俊艳,张琪,于洋,李昆鹰,刁标,宋小宝,乔杉,魏翔,艾伦,孙越,文松,潘斌龙,张一鸣,张子栋,修睿,衣云鹤,卜钰,李会长,王喳喳,古筝
周云鹏,鄂靖文,范湉湉
吕艳婷,囧森瑟夫,瀚墨,陈浩,绿绮,张珈铭,杨卫,王德顺,雨辰,李南,周泳汐,韩雨泽,南屿,张运气,杏林儿,王智行,张稷,良生,幻听,零柒,龚格尔,陈厚霖
王宝强,刘昊然,周润发,白客,张新成,岳云鹏,约翰·库萨克,太保,王雨甜,张傲月,柯国庆,萨姆·海登·史密斯,肖恩·科恩克,暗真,魏翔,尹正,安娜,奚美娟,李诚儒,小沈阳,冯文娟,桑平,曹瑞,王皓,陈创,蒋易,李宛妲
乔杉,张本煜,韩云云,何欢,李雪琴,尚语贤,海一天,九孔,种丹妮
奥利维娅·科尔曼,杰西·巴克利,艾琳·阿特金斯,蒂莫西·斯波,洛利·阿德福普,休·斯金纳,杰玛·琼斯,乔安娜·斯坎伦,阿丽莎·威尔,安贾纳·瓦桑,马拉基·卡比,格兰特·克鲁克斯